Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD741P)

Drug Name

Alagebrium chloride Drug Info

Synonyms

PTB; Tetrazolium chloride; ALT-711; ALT-766; N-phenacylthiazolium bromide; Advanced glycosylation end product (AGE)breakers, Alteon; Advanced glycosylation end product (AGE) breakers, Synvista

Indication

Disease Entry	ICD 11	Status	REF
Hypotension	BA20-BA21	Phase 2/3	[1]

Cross-matching ID

PubChem CID: 216306
CAS Number: CAS 341028-37-3
TTD Drug ID: DMD741P

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Advanced glycosylation end product receptor (AGER)	TTMO9HF	RAGE_HUMAN	Breaker	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Advanced glycosylation end product receptor (AGER)	DTT	AGER	4.347	2.379	1.945	4.233

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Hypotension

ICD Disease Classification

BA20-BA21

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Advanced glycosylation end product receptor (AGER)	DTT	AGER	7.92E-01	6.77E-03	0.04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT01417663) Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function. U.S. National Institutes of Health.
2	Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage. Trans Am Ophthalmol Soc. 2009 Dec;107:146-58.