Details of the Drug

General Information of Drug (ID: DMD741P)

• Drug Name: Alagebrium chloride
• Synonyms: PTB; Tetrazolium chloride; ALT-711; ALT-766; N-phenacylthiazolium bromide; Advanced glycosylation end product (AGE)breakers, Alteon; Advanced glycosylation end product (AGE) breakers, Synvista

Indication

Disease Entry	ICD 11	Status	REF
Hypotension	BA20-BA21	Phase 2/3	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 267.77
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 3
  Hydrogen Bond Donor Count; 0
  Hydrogen Bond Acceptor Count; 3
• Chemical Identifiers:
  Formula: C13H14ClNOS
  IUPAC Name: 2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone;chloride
  Canonical SMILES: CC1=C(SC=[N+]1CC(=O)C2=CC=CC=C2)C.[Cl-]
  InChI: InChI=1S/C13H14NOS.ClH/c1-10-11(2)16-9-14(10)8-13(15)12-6-4-3-5-7-12;/h3-7,9H,8H2,1-2H3;1H/q+1;/p-1
  InChIKey: MKOMESMZHZNBIZ-UHFFFAOYSA-M
• Cross-matching ID:
  PubChem CID: 216306
  CAS Number: 341028-37-3
  TTD ID: D07JLM

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Advanced glycosylation end product receptor (AGER)	TTMO9HF	RAGE_HUMAN	Breaker	[2]

Molecular Expression Atlas of This Drug

• The Studied Disease: Hypotension
• ICD Disease Classification: BA20-BA21

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Advanced glycosylation end product receptor (AGER)	DTT	AGER	7.92E-01	6.77E-03	0.04

References

• [1] ClinicalTrials.gov (NCT01417663) Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function. U.S. National Institutes of Health.
• [2] Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage. Trans Am Ophthalmol Soc. 2009 Dec;107:146-58.