Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDBJCY)

Drug Name

3-hydroxy-4-methyl-6H-benzo[c]chromen-6-one Drug Info

Synonyms

3-hydroxy-4-methyl-6H-benzo[c]chromen-6-one; 3-hydroxy-4-methylbenzo[c]chromen-6-one; CHEMBL203519; 76244-77-4; CBMicro_031406; AC1NT8BO; AC1Q2GPY; Oprea1_200366; SCHEMBL6825266; MolPort-000-688-996; ALBB-015456; ZINC5921519; BDBM50180504; STL466134; AKOS002377900; MCULE-5900160059; NS-02841; BIM-0031475.P001; R5445; 4-Methyl-3-hydroxy-6H-dibenzo[b,d]pyran-6-one; SR-01000229483; SR-01000229483-1; 6H-Dibenzo[b,d]pyran-6-one, 3-hydroxy-4-methyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5348729
TTD Drug ID: DMDBJCY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen receptor beta (ESR2)	TTOM3J0	ESR2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Estrogen receptor beta (ESR2)	DTT	ESR2	3.365	3.776	3.485	3.036

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Estrogen receptor beta (ESR2)	DTT	ESR2	2.09E-01	-0.06	-0.17

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72.