Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTOM3J0)

• DTT Name: Estrogen receptor beta (ESR2)
• Synonyms: Oestrogen receptor beta; Nuclear receptor subfamily 3 group A member 2; NR3A2; Erbeta; ESTRB; ER-beta; Beta-1
• Gene Name: ESR2
• DTT Type: Successful target; [1]
• Related Disease:
  Breast cancer [ICD-11: 2C60-2C6Y]
  Cushing syndrome [ICD-11: 5A70]
  Menopausal disorder [ICD-11: GA30]
  Vasomotor/allergic rhinitis [ICD-11: CA08]
• BioChemical Class: Nuclear hormone receptor
• UniProt ID: ESR2_HUMAN
• TTD ID: T80896
• Sequence:
  MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
  NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
  RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
  NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
  CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
  LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
  VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
  DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
  CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
• Function: Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. Nuclear hormone receptor.
• Reactome Pathway: Nuclear Receptor transcription pathway (R-HSA-383280)

Molecular Interaction Atlas (MIA) of This DTT

4 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARZOXIFENE	DMOKCVI	Breast cancer	2C60-2C65	Approved	[2]
Conjugated estrogens	DMLT0E1	Menopause symptom	GA30.0	Approved	[1], [3]
Estrogen	DMGY0UT	Menopause symptom	GA30.0	Approved	[4]
Trilostane	DMQZ9GF	Cushing disease	5A70	Approved	[5]

9 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MF-101	DM8Z0I3	Hepatitis virus infection	1E50-1E51	Phase 3	[6]
Premarin/Pravachol	DMLSOB7	Hyperlipidaemia	5C80	Phase 3	[7]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[8]
AUS-131	DMZMSQJ	Hot flushes	GA30	Phase 2	[9]
ERB-041	DMCEPUA	Inflammatory bowel disease	DD72	Phase 2	[10], [11]
Erteberel	DMU1XZD	Prostate hyperplasia	GA90	Phase 2	[12]
VG-101	DMAN21O	Menopause symptom	GA30.0	Phase 1/2	[13]
ERB-257	DMKMR2X	Sepsis	1G40-1G41	Phase 1	[14]
Naringenin	DMHAZLM	N. A.	N. A.	Phase 1	[15]

9 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bithionol	DMPJKRL	Trematode infection	1F8Y	Withdrawn from market	[16]
HEXESTROL	DM9AGWQ	Irregularities	N.A.	Withdrawn from market	[17]
EM-800	DM5JUW0	Estrogen deficiency	FB83.0Y	Discontinued in Phase 3	[18]
ERA-923	DM6NTAS	Breast cancer	2C60-2C65	Discontinued in Phase 2	[19]
ERB-196	DMGX08C	Inflammatory bowel disease	DD72	Discontinued in Phase 1	[20]
HE2100	DMCP2KH	Thrombocytopenia	3B64	Discontinued in Phase 1	[21]
ICI-164384	DMYN3WG	Breast cancer	2C60-2C65	Terminated	[22]
LY-117018	DMUHG0F	N. A.	N. A.	Terminated	[23]
ZK-119010	DMKFYDE	Carcinoma	2A00-2F9Z	Terminated	[24]

161 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,2-Bis-(4-hydroxy-phenyl)-3H-inden-5-ol	DM9RF1T	Discovery agent	N.A.	Investigative	[25]
1,8-Dichloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol	DMKJBRZ	Discovery agent	N.A.	Investigative	[26]
1-Bromo-6-(4-hydroxy-phenyl)-naphthalen-2-ol	DM2T4NL	Discovery agent	N.A.	Investigative	[26]
1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL	DM0MGFQ	Discovery agent	N.A.	Investigative	[27], [26]
1-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol	DM8BC1M	Discovery agent	N.A.	Investigative	[26]
2,3-diphenyl-1H-indole	DMC3UYH	Discovery agent	N.A.	Investigative	[28]
2-(2-Chloro-4-hydroxy-phenyl)-benzooxazol-5-ol	DMWDV71	Discovery agent	N.A.	Investigative	[29]
2-(3-Butoxy-4-hydroxy-phenyl)-benzooxazol-6-ol	DMJM5VW	Discovery agent	N.A.	Investigative	[29]
2-(3-Chloro-4-hydroxy-phenyl)-benzooxazol-5-ol	DMBONUV	Discovery agent	N.A.	Investigative	[29]
2-(3-Chloro-4-hydroxy-phenyl)-benzooxazol-6-ol	DM3B6IN	Discovery agent	N.A.	Investigative	[29]
2-(3-Fluoro-4-hydroxy-phenyl)-benzooxazol-5-ol	DMNTHK5	Discovery agent	N.A.	Investigative	[29]
2-(3-Fluoro-4-hydroxy-phenyl)-benzooxazol-6-ol	DM50FW1	Discovery agent	N.A.	Investigative	[29]
2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol	DMZCE18	Discovery agent	N.A.	Investigative	[30]
2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-6-ol	DMIGXRJ	Discovery agent	N.A.	Investigative	[30]
2-(4-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol	DMUGHF6	Discovery agent	N.A.	Investigative	[29]
2-(4-Hydroxy-phenyl)-1-p-tolyl-3H-inden-5-ol	DMBIV8F	Discovery agent	N.A.	Investigative	[25]
2-(4-Hydroxy-phenyl)-4-methoxy-quinolin-6-ol	DM4N0LB	Discovery agent	N.A.	Investigative	[31]
2-(4-Hydroxy-phenyl)-4-vinyl-quinolin-6-ol	DM81G2U	Discovery agent	N.A.	Investigative	[31]
2-(4-Hydroxy-phenyl)-7-isopropyl-benzooxazol-5-ol	DMFWOMY	Discovery agent	N.A.	Investigative	[29]
2-(4-Hydroxy-phenyl)-7-methoxy-benzofuran-5-ol	DMY0I8P	Discovery agent	N.A.	Investigative	[32]
2-(4-Hydroxy-phenyl)-7-methoxy-benzooxazol-5-ol	DMCNITS	Discovery agent	N.A.	Investigative	[29]
2-(4-Hydroxy-phenyl)-7-methyl-benzofuran-5-ol	DMQ2KPI	Discovery agent	N.A.	Investigative	[32]
2-(4-Hydroxy-phenyl)-7-phenyl-benzooxazol-5-ol	DMUB7KH	Discovery agent	N.A.	Investigative	[29]
2-(4-Hydroxy-phenyl)-7-propenyl-benzooxazol-5-ol	DMND63Z	Discovery agent	N.A.	Investigative	[29]
2-(4-Hydroxy-phenyl)-7-propyl-benzooxazol-5-ol	DMONT2D	Discovery agent	N.A.	Investigative	[29]
2-(4-Hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol	DM2F6U3	Discovery agent	N.A.	Investigative	[29]
2-(4-Hydroxy-phenyl)-benzooxazol-5-ol	DMMUNA7	Discovery agent	N.A.	Investigative	[29]
2-(4-Hydroxy-phenyl)-benzooxazol-6-ol	DM31MY0	Discovery agent	N.A.	Investigative	[29]
2-(4-Hydroxy-phenyl)-quinolin-6-ol	DMCWFUZ	Discovery agent	N.A.	Investigative	[31]
2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL	DMN6S3F	Discovery agent	N.A.	Investigative	[27], [29]
2-(4-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol	DMW6L38	Discovery agent	N.A.	Investigative	[30]
2-(5-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol	DMB3JG0	Discovery agent	N.A.	Investigative	[29]
2-(6-Hydroxy-naphthalen-1-yl)-benzooxazol-5-ol	DMXAVHT	Discovery agent	N.A.	Investigative	[29]
2-(6-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol	DM3GQN2	Discovery agent	N.A.	Investigative	[29]
2-(6-Hydroxy-naphthalen-2-yl)-benzooxazol-5-ol	DM715EC	Discovery agent	N.A.	Investigative	[29]
2-(6-Hydroxy-naphthalen-2-yl)-benzooxazol-6-ol	DMANHOT	Discovery agent	N.A.	Investigative	[29]
2-Naphthalen-1-yl-benzooxazol-6-ol	DMBI6U9	Discovery agent	N.A.	Investigative	[29]
2-phenyl-1,2'-spirobi[1H-indene]-5'-ol	DMP8G3C	Discovery agent	N.A.	Investigative	[30]
3'-Methoxy-4'Hydroxyclomiphene	DMG1T6H	Discovery agent	N.A.	Investigative	[33]
3,4,6-Trihydroxy-2-(4-hydroxy-phenyl)-inden-1-one	DM3MAEQ	Discovery agent	N.A.	Investigative	[34]
3,6-Dihydroxy-2-(4-hydroxy-phenyl)-inden-1-one	DMUH4OV	Discovery agent	N.A.	Investigative	[34]
3,8-dihydroxy-4-methyl-6H-benzo[c]chromen-6-one	DMIFJRS	Discovery agent	N.A.	Investigative	[35]
3,8-dihydroxy-7-methyl-6H-benzo[c]chromen-6-one	DMW0B4H	Discovery agent	N.A.	Investigative	[35]
3-(2-Hydroxy-phenyl)-benzo[d]isoxazol-6-ol	DMD24EW	Discovery agent	N.A.	Investigative	[29]
3-(4-Hydroxy-phenyl)-4H-chromen-7-ol	DMN01PI	Discovery agent	N.A.	Investigative	[36]
3-(4-Hydroxy-phenyl)-benzo[d]isoxazol-5-ol	DMXZ9T6	Discovery agent	N.A.	Investigative	[29]
3-(4-Hydroxy-phenyl)-benzo[d]isoxazol-6-ol	DMYLDFG	Discovery agent	N.A.	Investigative	[29]
3-(5-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol	DMPRBLH	Discovery agent	N.A.	Investigative	[29]
3-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol	DM5H9QT	Discovery agent	N.A.	Investigative	[29]
3-chloro-4-(4-hydroxyphenyl)salicylaldoxime	DMER4U1	Discovery agent	N.A.	Investigative	[37]
3-hydroxy-4,10-dimethyl-6H-benzo[c]chromen-6-one	DMEJQTA	Discovery agent	N.A.	Investigative	[35]
3-hydroxy-4,7-dimethyl-6H-benzo[c]chromen-6-one	DMUME74	Discovery agent	N.A.	Investigative	[35]
3-hydroxy-4-methyl-6H-benzo[c]chromen-6-one	DMDBJCY	Discovery agent	N.A.	Investigative	[35]
3-hydroxy-8,10-dimethyl-6H-benzo[c]chromen-6-one	DM3H56L	Discovery agent	N.A.	Investigative	[35]
3-[1-ethyl-2-(3-hydroxyphenyl)butyl]phenol	DMPTI1Z	Discovery agent	N.A.	Investigative	[38]
4',5,7-trihydroxy-6,8-dimethylisoflavone	DM1RM3H	Discovery agent	N.A.	Investigative	[39]
4,10-dimethyl-6H-benzo[c]chromene-3,8-diol	DMB5RJK	Discovery agent	N.A.	Investigative	[35]
4,6,10-trimethyl-6H-benzo[c]chromene-3,8-diol	DM6N98E	Discovery agent	N.A.	Investigative	[35]
4,6,6,7-tetramethyl-6H-benzo[c]chromene-3,8-diol	DM14VI3	Discovery agent	N.A.	Investigative	[35]
4,6,7,10-tetramethyl-6H-benzo[c]chromene-3,8-diol	DMYN25U	Discovery agent	N.A.	Investigative	[35]
4,6,7-trimethyl-6H-benzo[c]chromene-3,8-diol	DMFECXI	Discovery agent	N.A.	Investigative	[35]
4,7-dimethyl-6H-benzo[c]chromene-3,8-diol	DM67Z81	Discovery agent	N.A.	Investigative	[35]
4-(2-phenyl-1H-benzo[d]imidazol-1-yl)phenol	DMFQZOI	Discovery agent	N.A.	Investigative	[28]
4-(2-phenyl-1H-indol-3-yl)phenol	DMCPSE9	Discovery agent	N.A.	Investigative	[28]
4-(3-(4-hydroxyphenyl)-1H-indol-2-yl)phenol	DMR3T2D	Discovery agent	N.A.	Investigative	[28]
4-(3-phenyl-1H-indol-2-yl)phenol	DMEJF6V	Discovery agent	N.A.	Investigative	[28]
4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME	DMZT6HL	Discovery agent	N.A.	Investigative	[27]
4-(5-Hydroxy-benzooxazol-2-yl)-benzene-1,3-diol	DM1EANV	Discovery agent	N.A.	Investigative	[29]
4-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol	DM38YZ4	Discovery agent	N.A.	Investigative	[29]
4-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,3-diol	DM07NT9	Discovery agent	N.A.	Investigative	[29]
4-Benzo[d]isoxazol-3-yl-benzene-1,3-diol	DM1UG2A	Discovery agent	N.A.	Investigative	[29]
4-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol	DMPSRAC	Discovery agent	N.A.	Investigative	[31]
4-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol	DMKJ18X	Discovery agent	N.A.	Investigative	[31]
4-Ethyl-2-(4-hydroxy-phenyl)-quinolin-6-ol	DMTIY89	Discovery agent	N.A.	Investigative	[31]
4-Ethynyl-2-(4-hydroxy-phenyl)-quinolin-6-ol	DMXLZAT	Discovery agent	N.A.	Investigative	[31]
4-Naphthalen-2-yl-phenol	DMKPNSH	Discovery agent	N.A.	Investigative	[26]
4-[1,2-bis(4-hydroxyphenyl)but-1-enyl]phenol	DMW1IXY	Discovery agent	N.A.	Investigative	[40]
4-[1,2-bis(4-hydroxyphenyl)hex-1-enyl]phenol	DMTL6ES	Discovery agent	N.A.	Investigative	[40]
4-[1,2-bis(4-hydroxyphenyl)pent-1-enyl]phenol	DMTHG0Y	Discovery agent	N.A.	Investigative	[40]
4-[1,2-bis(4-hydroxyphenyl)vinyl]phenol	DMR7GP6	Discovery agent	N.A.	Investigative	[40]
4-[2,2-bis(4-hydroxyphenyl)-1-methylvinyl]phenol	DMS0HV6	Discovery agent	N.A.	Investigative	[40]
5,7-dihydroxy-3-phenyl-3H-quinazolin-4-one	DMA61I2	Discovery agent	N.A.	Investigative	[41]
5-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol	DM2YL0T	Discovery agent	N.A.	Investigative	[31]
5-Chloro-2-(4-hydroxy-phenyl)-benzooxazol-6-ol	DMCFIZN	Discovery agent	N.A.	Investigative	[29]
5-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol	DMXNPSB	Discovery agent	N.A.	Investigative	[31]
6-(2,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol	DMRU963	Discovery agent	N.A.	Investigative	[26]
6-(2,6-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol	DMFALTY	Discovery agent	N.A.	Investigative	[26]
6-(2-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol	DMTPAMS	Discovery agent	N.A.	Investigative	[26]
6-(2-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol	DM6Q3M7	Discovery agent	N.A.	Investigative	[26]
6-(2-Hydroxy-phenyl)-naphthalen-2-ol	DMM3798	Discovery agent	N.A.	Investigative	[26]
6-(3,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol	DMKJOL6	Discovery agent	N.A.	Investigative	[26]
6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol	DM4YP3Q	Discovery agent	N.A.	Investigative	[26]
6-(3-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol	DMAJEDG	Discovery agent	N.A.	Investigative	[26]
6-(3-Hydroxy-phenyl)-naphthalen-1-ol	DMMHRVO	Discovery agent	N.A.	Investigative	[26]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol	DMH8WA2	Discovery agent	N.A.	Investigative	[26]
6-(4-Hydroxy-2-methoxy-phenyl)-naphthalen-2-ol	DMYM3EW	Discovery agent	N.A.	Investigative	[26]
6-(4-Hydroxy-2-methyl-phenyl)-naphthalen-2-ol	DMYEIRH	Discovery agent	N.A.	Investigative	[26]
6-(4-Hydroxy-phenyl)-1-methoxy-naphthalen-2-ol	DMBG5Y8	Discovery agent	N.A.	Investigative	[26]
6-(4-Hydroxy-phenyl)-1-methyl-naphthalen-2-ol	DMGLT0N	Discovery agent	N.A.	Investigative	[26]
6-(4-Hydroxy-phenyl)-1-nitro-naphthalen-2-ol	DMGC84U	Discovery agent	N.A.	Investigative	[26]
6-(4-Hydroxy-phenyl)-1-phenyl-naphthalen-2-ol	DMI6UVN	Discovery agent	N.A.	Investigative	[26]
6-(4-Hydroxy-phenyl)-naphthalen-1-ol	DM2V9XI	Discovery agent	N.A.	Investigative	[26]
6-(4-Hydroxy-phenyl)-naphthalen-2-ol	DM3L2OI	Discovery agent	N.A.	Investigative	[31]
6-Chloro-2-(4-hydroxy-phenyl)-benzooxazol-5-ol	DMLMOC0	Discovery agent	N.A.	Investigative	[29]
6-ethyl-4,7-dimethyl-6H-benzo[c]chromene-3,8-diol	DMOGETD	Discovery agent	N.A.	Investigative	[35]
6-Phenyl-naphthalen-2-ol	DMEYOF7	Discovery agent	N.A.	Investigative	[26]
7-(3-Hydroxy-phenyl)-naphthalen-2-ol	DM2I91C	Discovery agent	N.A.	Investigative	[26]
7-(4-Hydroxy-phenyl)-naphthalen-2-ol	DMM9IXB	Discovery agent	N.A.	Investigative	[26]
7-Allyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol	DMSRQ1L	Discovery agent	N.A.	Investigative	[29]
7-Bromo-2-(4-hydroxy-phenyl)-benzofuran-5-ol	DMA8DXG	Discovery agent	N.A.	Investigative	[32]
7-Butyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol	DMQ8BIX	Discovery agent	N.A.	Investigative	[29]
7-Chloro-2-(4-hydroxy-phenyl)-benzofuran-5-ol	DM38HKE	Discovery agent	N.A.	Investigative	[32]
7-Ethyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol	DMUMN4B	Discovery agent	N.A.	Investigative	[29]
7-Ethynyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol	DM92EG5	Discovery agent	N.A.	Investigative	[29]
7-hydroxy-1,2,9,9a-tetrahydrofluoren-3-one	DMKSJE3	Discovery agent	N.A.	Investigative	[42]
7-hydroxy-3-(4-hydroxyphenyl)-3H-quinazolin-4-one	DM46J2H	Discovery agent	N.A.	Investigative	[41]
7-Phenyl-naphthalen-2-ol	DM1WJFR	Discovery agent	N.A.	Investigative	[26]
8-(2,2-dimethylpropyl)naringenin	DMV5FZO	Discovery agent	N.A.	Investigative	[15]
8-(2-methylpropyl)naringenin	DMQUZSJ	Discovery agent	N.A.	Investigative	[15]
8-(3-methylbutyl)naringenin	DM2VAJE	Discovery agent	N.A.	Investigative	[15]
8-benzylnaringenin	DMKHF87	Discovery agent	N.A.	Investigative	[15]
8-Chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol	DMB76ZN	Discovery agent	N.A.	Investigative	[26]
8-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol	DMGJ3L6	Discovery agent	N.A.	Investigative	[26]
8-methylnaringenin	DMK63P2	Discovery agent	N.A.	Investigative	[15]
8-n-heptylnaringenin	DMWMVI3	Discovery agent	N.A.	Investigative	[15]
8-n-nonylnaringenin	DMC2JLQ	Discovery agent	N.A.	Investigative	[15]
8-n-pentylnaringenin	DMRDOP0	Discovery agent	N.A.	Investigative	[15]
8-n-propylnaringenin	DMDOW5S	Discovery agent	N.A.	Investigative	[15]
8-n-undecylnaringenin	DMXURM8	Discovery agent	N.A.	Investigative	[15]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[43]
Bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[44]
BROUSSONIN A	DMXFN6H	Discovery agent	N.A.	Investigative	[45]
Coumestrol	DM40TBU	Discovery agent	N.A.	Investigative	[36]
CP-394531	DMDPH3W	Discovery agent	N.A.	Investigative	[46]
CP-409069	DM1U6P7	Discovery agent	N.A.	Investigative	[46]
Daidzein	DMRFTJX	Discovery agent	N.A.	Investigative	[39]
diarylpropionitril	DM14X29	Discovery agent	N.A.	Investigative	[47]
DIHYDRORALOXIFENE	DM70OIC	Discovery agent	N.A.	Investigative	[48]
Doxorubicin-Formaldehyde Conjugate	DMJF6AQ	Discovery agent	N.A.	Investigative	[49]
EFFUSOL	DMXZRND	Discovery agent	N.A.	Investigative	[35]
ERB-002	DMYRDBX	Inflammation	1A00-CA43.1	Investigative	[50]
Geldanamycin-estradiol hybrid	DMUSJ96	Discovery agent	N.A.	Investigative	[51]
GNF-PF-3037	DM4RZSB	Discovery agent	N.A.	Investigative	[16]
GTx-822	DMEIMVW	Ocular disease	1F00.1Z	Investigative	[50]
GTx-878	DMP9OGC	Prostate hyperplasia	GA90	Investigative	[50]
HPTE	DMRPZD4	Discovery agent	N.A.	Investigative	[52]
KB-9520	DMCQRA3	Solid tumour/cancer	2A00-2F9Z	Investigative	[50]
Morin	DM2OGZ5	Discovery agent	N.A.	Investigative	[16]
Nafoxidine	DM0FROP	Discovery agent	N.A.	Investigative	[53]
NDC-1022	DM7NJI2	Solid tumour/cancer	2A00-2F9Z	Investigative	[50]
Para-Mercury-Benzenesulfonic Acid	DMQVFWJ	Discovery agent	N.A.	Investigative	[43]
PHTPP	DMBHKAV	Discovery agent	N.A.	Investigative	[54]
R,R-THC	DM4URMA	Discovery agent	N.A.	Investigative	[55]
SOPHORAFLAVANONE B	DMUVKX5	Discovery agent	N.A.	Investigative	[15]
THIOGENISTEIN	DMK2J5L	Discovery agent	N.A.	Investigative	[41]
Trans-hydroxytamoxifen	DMXS8LN	Discovery agent	N.A.	Investigative	[56]
TUPICHINOL C	DMAUTRP	Discovery agent	N.A.	Investigative	[45]
WAY-169916	DM94KWA	Discovery agent	N.A.	Investigative	[57]
WAY200070	DMBHXTL	Discovery agent	N.A.	Investigative	[29]
ZK-164015	DMROWV8	Discovery agent	N.A.	Investigative	[58]
[1,1':2',1'']Terphenyl-4'-carbaldehyde oxime	DMFXA8P	Discovery agent	N.A.	Investigative	[59]

Molecular Expression Atlas (MEA) of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Neonatal sepsis	1G41	Whole blood	6.89E-01	0.03	0.14
Prostate cancer	2C82	Prostate	2.09E-01	-0.06	-0.17
Breast cancer	2C82	Breast tissue	1.12E-20	-0.22	-0.7

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