Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDSVRP)

Drug Name
DV-1179 Drug Info
Indication
Disease Entry ICD 11 Status REF
Autoimmune disease 4A40-4A45 Phase 1 [1]
Systemic lupus erythematosus 4A40.0 Discontinued in Phase 1 [2]
Cross-matching ID
TTD Drug ID
DMDSVRP

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 7 (TLR7) TTRJ1K4 TLR7_HUMAN Modulator [3]
Toll-like receptor 9 (TLR9) TTSHG0T TLR9_HUMAN Modulator [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Toll-like receptor 7 (TLR7) DTT TLR7 3.7 0.848 -0.152 3.121
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Autoimmune disease
ICD Disease Classification 4A40-4A45
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Toll-like receptor 7 (TLR7) DTT TLR7 3.32E-25 0.44 0.88
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035150)
3 Company report (Dynavax)