Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDY3I2)

Drug Name

Quinoline-2-carboxylic acid adamantan-1-ylamide Drug Info

Synonyms

CHEMBL399161; AC1ME9EW; quinoline-2-carboxylic acid adamantan-1-ylamide; Oprea1_069959; SCHEMBL6084070; MolPort-002-116-284; ZINC4776255; STK208477; N-1-adamantylquinoline-2-carboxamide; BDBM50231752; AKOS001569250; MCULE-4553069817; N-(1-adamantyl)quinoline-2-carboxamide; SR-01000399357; SR-01000399357-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2851338
TTD Drug ID: DMDY3I2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 1 (mGluR1)	TTVBPDM	GRM1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	3.888	3.848	3.711	3.678

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	2.31E-01	-0.05	-0.2
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	2.46E-02	0.11	0.74

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47.