Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDYC4J)

Drug Name
PMID23489211C20 Drug Info
Synonyms PCM126; GTPL8124; BDBM50428059
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
71718651
TTD Drug ID
DMDYC4J

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ephrin type-A receptor 1 (EPHA1) TTLFZVU EPHA1_HUMAN Inhibitor [1]
Ephrin type-A receptor 2 (EPHA2) TTRJB2G EPHA2_HUMAN Inhibitor [1]
Ephrin type-A receptor 3 (EPHA3) TTHS2LR EPHA3_HUMAN Inhibitor [1]
Ephrin type-A receptor 4 (EPHA4) TTG84D3 EPHA4_HUMAN Inhibitor [1]
Ephrin type-A receptor 5 (EPHA5) TTV9KOD EPHA5_HUMAN Inhibitor [1]
Ephrin type-A receptor 6 (EPHA6) TTFAHWI EPHA6_HUMAN Inhibitor [1]
Ephrin type-A receptor 7 (EPHA7) TTAHTVG EPHA7_HUMAN Inhibitor [1]
Ephrin type-A receptor 8 (EPHA8) TTHZ2LW EPHA8_HUMAN Inhibitor [1]
Ephrin type-B receptor 1 (EPHB1) TT8MDAC EPHB1_HUMAN Inhibitor [1]
Ephrin type-B receptor 2 (EPHB2) TTKPV6O EPHB2_HUMAN Inhibitor [1]
Ephrin type-B receptor 3 (EPHB3) TT5LM7U EPHB3_HUMAN Inhibitor [1]
Ephrin type-B receptor 4 (EPHB4) TTI4ZX2 EPHB4_HUMAN Inhibitor [1]
Ephrin type-B receptor 6 (EPHB6) TTZEMUY EPHB6_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Ephrin type-B receptor 4 (EPHB4) DTT EPHB4 5.771 6.362 6.05 5.594
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Ephrin type-B receptor 4 (EPHB4) DTT EPHB4 4.05E-01 6.00E-03 0.02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47.