Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDYVN8)

• Drug Name: MEDI-528 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Phase 2	[1]

• Cross-matching ID: TTD Drug ID: DMDYVN8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-9 (IL9)	TT0JTFD	IL9_HUMAN	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Interleukin-9 (IL9)	DTT	IL9	2.35	1.766	2.104	1.926

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 12 Disease of the respiratory system
• Disease Class: ICD-11: CA23 Asthma
• The Studied Tissue: Nasal and bronchial airway
• The Studied Disease: Asthma [ICD-11:CA23]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interleukin-9 (IL9)	DTT	IL9	8.78E-01	-0.03	-0.09

References

• [1] ClinicalTrials.gov (NCT00507130) A Study to Evaluate the Safety and Tolerability of the Administration of MEDI-528 When Administered in Multiple Doses to Adults With Mild Persistent Asthma
• [2] Clinical pipeline report, company report or official report of AstraZeneca (2009).