Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMECWL1)

Drug Name

8-(2,6-Dichloro-phenyl)-9H-purine-2,6-diamine Drug Info

Synonyms

CHEMBL318601; 8-(2,6-dichlorophenyl)-9H-purine-2,6-diamine; 8-(2,6-dichlorophenyl)-7H-purine-2,6-diamine; AC1LAR9F; 8-(2,6-Dichloro-phenyl)-9H-purine-2,6-diamine; CTK7E1079; BDBM50059926

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 473574
TTD Drug ID: DMECWL1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polypeptide deformylase (PDF)	TT9SL3Q	DEFM_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Polypeptide deformylase (PDF)	DTT	PDF	8.87E-16	-0.54	-0.86

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneum... J Med Chem. 1997 Sep 12;40(19):3032-9.