Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEGMA2)

Drug Name

ETH615 Drug Info

Synonyms

Eth 615; Eth-615; 133430-69-0; CHEMBL310584; AC1L2ZIP; SCHEMBL7749388; DTXSID50158106; BDBM50006807; 4-({(3-Fluoro-benzyl)-[4-(quinolin-2-ylmethoxy)-phenyl]-amino}-methyl)-benzoic acid; Benzoic acid, 4-((((3-fluorophenyl)methyl)(4-(2-quinolinylmethoxy)phenyl)amino)methyl)-; 4-[[N-[(3-fluorophenyl)methyl]-4-(quinolin-2-ylmethoxy)anilino]methyl]benzoic acid

Indication

Disease Entry	ICD 11	Status	REF
Dermatitis	EA80-EA89	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 131627
CAS Number: CAS 133430-69-0
TTD Drug ID: DMEGMA2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Dermatitis

ICD Disease Classification

EA80-EA89

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006733)
2	Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45.