Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEI890)

Drug Name

FV-Aib-TDVGPFAF Drug Info

Synonyms

[Aib29,Asp31,Pro34,Phe35]CGRP(27-37)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcitonin gene-related peptide 1 (CALCA)	TTVSFJW	CALCA_HUMAN	Inhibitor	[1]
Calcitonin gene-related peptide receptor (CGRPR)	TTY6O0Q	CALRL_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Calcitonin gene-related peptide 1 (CALCA)	DTT	CALCA	5.221	2.818	4.501	4.647

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Calcitonin gene-related peptide 1 (CALCA)	DTT	CALCA	1.80E-07	-0.32	-0.62

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97.
2	Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor. J Med Chem. 2006 Jan 26;49(2):616-24.