Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEX6AM)

Drug Name

2-amino-2-(3-bromophenyl)acetic acid Drug Info

Synonyms

2-amino-2-(3-bromophenyl)acetic Acid; 79422-73-4; Amino(3-bromophenyl)acetic acid; 3-Bromo-DL-phenylglycine; CHEMBL382371; 150174-93-9; Amino-(3-bromo-phenyl)-acetic acid; Benzeneacetic acid, a-amino-3-bromo-; 3-Bromo-L-phenylglycine; (+)-2-Amino-2-(3-bromophenyl)acetic acid; (S)-2-(3-BROMOPHENYL)GLYCINE; AC1MXE2V; 2-(3-Bromophenyl)glycine; SCHEMBL2927725; AMGLY00125; AC1Q505E; CTK5E6784; KS-00000MGC; DTXSID80396791; MolPort-000-000-540; MJPMYLPJAVQUQA-UHFFFAOYSA-N; N-(3-BROMOPHENYL)-GLYCINE; ANW-43657; MFCD00665358; BDBM50179696

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3814142
CAS Number: CAS 79422-73-4
TTD Drug ID: DMEX6AM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	TTFK1JQ	CA2D1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	5.083	4.833	5.343	2.536

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	9.36E-01	-0.03	-0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	2.81E-05	-0.15	-0.68

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.