Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMF38M5)

Drug Name

4-Bromo-N-hydroxy-benzamide Drug Info

Synonyms

4-Bromo-N-hydroxybenzamide; 4-Bromo-N-hydroxy-benzamide; 1836-27-7; CHEMBL351337; 4-bromobenzenecarbohydroxamic acid; p-Bromobenzohydroxamic acid; AC1LCOKZ; N-Hydroxy-4-bromobenzamide; p-bromophenylhydroxamic acid; 4-Bromo-N-hydroxybenzamide #; SCHEMBL8575405; Benzamide, 4-bromo-N-hydroxy-; CTK0E2598; DTXSID20345349; VESPFSJNQMGUCQ-UHFFFAOYSA-N; MolPort-002-985-506; ZINC5249551; STK249669; BDBM50015106; AKOS000175576; MCULE-4510290140; DA-16649; SC-53612; KB-290158; ST51029575; FT-0708429

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 603910
CAS Number: CAS 1836-27-7
TTD Drug ID: DMF38M5

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8.