Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMF6WHC)

• Drug Name: (1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methanol Drug Info
• Synonyms: 63006-93-9; (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol; 1,2,3,4-Tetrahydroisoquinoline-3-methanol; (1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methanol; 1,2,3,4-tetrahydroisoquinolin-3-ylmethanol; (S)-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol; 62928-94-3; CHEMBL60068; 1,2,3,4-tetrahydro-3-isoquinolinemethanol; 3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-; 3-Hydroxymethyl-1,2,3,4-tetrahydroisoquinoline; F2147-1627; PubChem5794; AC1MWNWL; (S)-1,2,3,4-Tetrahydroisoquinolylmethan-3-ol; ACMC-209err; ChemDiv2_003241

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3752277
  TTD Drug ID: DMF6WHC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

References

• [1] 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferas... J Med Chem. 1999 Jun 3;42(11):1982-90.