Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFAMNH)

Drug Name
99mTc-rBitistatin Drug Info
Indication
Disease Entry ICD 11 Status REF
Embolism JB42 Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DMFAMNH

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) TT38RM1 ITA2B_HUMAN; ITB3_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DTT ITGA2B 2.186 1.202 1.585 2.7
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Embolism
ICD Disease Classification JB42
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DTT ITGA2B; ITGB3 7.83E-01 -0.11 -0.45
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00808626) Phase II Investigation of 99mTc-rBitistatin for Imaging Venous Thrombosis. U.S. National Institutes of Health.
2 Platelet binding and biodistribution of [99mTc]rBitistatin in animal species and humans. Nucl Med Biol. 2007 Oct;34(7):855-63.