Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFHUGC)

• Drug Name: SB 269970-A Drug Info
• Synonyms: SB-269970 hydrochloride; 261901-57-9; SB 269970 hydrochloride; SB269970 HCl; (R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride; SB-269970 (hydrochloride); (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride; SR-01000076135; EU-0101059; SB269970 hydrochloride; C18H29ClN2O3S; MLS002153418; SB 269970 hcl; SCHEMBL2719586; CHEMBL1256844; KS-00000XMZ; CTK8B9470; SB-269970 HCl; MolPort-003-959-592; BCP14529; Tox21_501059; MFCD03788020; ANW-62575; s2849

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 11957684
  TTD Drug ID: DMFHUGC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 7 receptor (HTR7)	TTO9X1H	5HT7R_HUMAN	Antagonist	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 7 receptor (HTR7)	DTT	HTR7	1.561	1.233	0.848	1.485

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 7 receptor (HTR7)	DTT	HTR7	9.79E-01	-0.08	-0.32

References

• [1] 5-HT7 receptors. Curr Drug Targets CNS Neurol Disord. 2004 Feb;3(1):81-90.