Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFKRMG)

Drug Name

4-[3-(4-Butyl-phenoxy)-propyl]-1H-imidazole Drug Info

Synonyms

CHEMBL419654; 4-[3-(4-Butyl-phenoxy)-propyl]-1H-imidazole; SCHEMBL7991257; NKIFZJYIQSBUEI-UHFFFAOYSA-N; BDBM50093221; [3-(4-Imidazolyl)propyl](4-butylphenyl) ether; 4-Butylphenyl 3-(1H-imidazol-4-yl)propyl ether

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 21193574
TTD Drug ID: DMFKRMG

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histamine H3 receptor (H3R)	DTT	HRH3	3.225	3.399	3.17	3.027

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H3 receptor (H3R)	DTT	HRH3	3.62E-02	-0.09	-0.22

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2379-82.