Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFOM10)

Drug Name

8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine Drug Info

Synonyms

8-Methoxy-2-aminotetralin; 3880-77-1; 8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine; 8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine; CHEMBL26688; ACMC-20msdp; ACMC-20mscg; 2-amino-8-methoxytetralin; 8-methoxytetralin-2-amine; 8-methoxy-2-amino-tetralin; 2-Naphthalenamine,1,2,3,4-tetrahydro-8-methoxy-, (2R)-; 2-Naphthalenamine,1,2,3,4-tetrahydro-8-methoxy-, (2S)-; SCHEMBL266921; CTK4I0515; 2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-8-METHOXY-; RVKOHSCTEHZRRT-UHFFFAOYSA-N; MFCD00906373; BDBM50016733; AKOS022393176; FCH1122360

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10197933
CAS Number: CAS 3880-77-1
TTD Drug ID: DMFOM10

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993).