Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFPO16)

• Drug Name: 4',4-Dihydroxychalcone Drug Info
• Synonyms: 4,4'-Dihydroxychalcone; UNII-CKY3J88Z94; CKY3J88Z94; CHEMBL145927; 1,3-bis(4-hydroxyphenyl)prop-2-en-1-one; 4',4-Dihydroxychalcone; 3600-61-1; 4,4'-Dihydroxybenzylidene acetophenone; RVC 588 (chalcone); 4,4''-dihydroxychalcone; 4'',4-Dihydroxychalcone; AC1NV3S6; (E)-1,3-bis(4-hydroxyphenyl)prop-2-en-1-one; Trans-4,4'-dihydroxychalcone; SCHEMBL773588; (E)-4,4'-Dihydroxychalcone; 4,4'-Dihydroxychalcone, (E)-; 1,3-bis(4-hydroxyphenyl)propenone; ZINC5843955; NSC652891; LMPK12120193; BDBM50068224; AKOS022660924; NSC-652891

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5467477
  CAS Number: CAS 3600-61-1
  TTD Drug ID: DMFPO16

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosinase (TYR)	DTT	TYR	5.959	5.711	5.973	4.912

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	6.68E-04	2.54	1.15

References

• [1] Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. Eur J Med Chem. 2010 May;45(5):2010-7.