Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFW1JC)

Drug Name
C-Naphthalen-1-yl-methylamine Drug Info
Synonyms
1-Naphthalenemethylamine; 118-31-0; naphthalen-1-ylmethanamine; 1-Naphthylmethylamine; 1-NAPHTHALENEMETHANAMINE; 1-(Aminomethyl)naphthalene; 1-Naphthalenemethyl amine; C-Naphthalen-1-yl-methylamine; 1-Naphthylmethanamine; (1-naphthylmethyl)amine hydrochloride; CHEMBL128633; 1-AMINOMETHYLNAPHTHALENE; naphthylmethylamine; NVSYANRBXPURRQ-UHFFFAOYSA-N; MFCD00004048; 1-Naphthalenemethylamine, 97%; Naphthalene-1-methylamine; naphtalenemethylamine; EINECS 204-244-0; naphth-1-ylmethylamine; 1-naphthylmethyl-amine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
8355
CAS Number
CAS 118-31-0
TTD Drug ID
DMFW1JC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-2A (ADRA2A) TTWG9A4 ADA2A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2B (ADRA2B) TTWM4TY ADA2B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 5.013 2.379 5.594 2.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005.