Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFW6Q0)

• Drug Name: 8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole Drug Info
• Synonyms: CHEMBL443258; 8-chloro-1H,2H,3H,4H-pyrazino[1,2-a]indole; 126718-22-7; 8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole; SCHEMBL5917499; MolPort-022-445-855; BDBM50108304; ZINC13586842; AKOS022692454; MCULE-6563903231; NE39901; 8-chloro-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 14595512
  TTD Drug ID: DMFW6Q0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2A receptor (HTR2A)	DTT	HTR2A	1.68E-01	-0.3	-0.14
5-HT 2A receptor (HTR2A)	DTT	HTR2A	5.59E-01	0.15	0.21

References

• [1] Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8.