Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFWA9Y)

• Drug Name: 2-p-tolyl-4H-chromen-4-one Drug Info
• Synonyms: 4'-Methylflavone; 2-(4-methylphenyl)-4H-chromen-4-one; 2-(4-methylphenyl)chromen-4-one; 2-p-Tolyl-chromen-4-one; CHEMBL16861; 2-p-tolyl-4H-chromen-4-one; 4'-Methylflavon; 4hlk; AC1LEMVU; Maybridge3_003060; Oprea1_528340; Oprea1_754899; 2-(p-tolyl)-chromen-4-one; SCHEMBL7593917; ZINC57876; MolPort-000-648-141; OPHKKQQCOYMLPW-UHFFFAOYSA-N; HMS1439L02; BDBM50310190; AKOS000603601; MCULE-3669298263; IDI1_014447; 41255-30-5; ST093690; BAS 01121718; NS-00120; 4H-1-Benzopyran-4-one, 2-(4-methylphenyl)-; AG-690/13115015

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 688829
  TTD Drug ID: DMFWA9Y

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07

References

• [1] A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9.