Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMG3HX2)

Drug Name
CV-6504 Drug Info
Synonyms
CV-6504; 117574-40-0; CV 6504; 2,3,5-Trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone; 2,5-Cyclohexadiene-1,4-dione,2,3,5-trimethyl-6-(3-pyridinylmethyl)-; ACMC-20mn9v; AC1L3QEW; ZINC4541; SCHEMBL2715544; CTK4B0337; DTXSID80151827; IPGAFOVEIIWXFR-UHFFFAOYSA-N; EX-A2681; 6-(3-pyridylmethyl)-2,3,5-trimethyl-1,4-benzoquinone; 2,5-Cyclohexadiene-1,4-dione, 2,3,5-trimethyl-6-(3-pyridinylmethyl)-
Cross-matching ID
PubChem CID
93543
CAS Number
CAS 117574-40-0
TTD Drug ID
DMG3HX2

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 4.966 5.133 5.358 6.128
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 7.42E-01 -0.18 -0.25
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 1.25E-03 0.43 0.63
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. Ann Oncol. 2000 Sep;11(9):1165-70.