Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMG5KDY)

Drug Name

PYROGALLOL Drug Info

Synonyms

pyrogallol; benzene-1,2,3-triol; 87-66-1; 1,2,3-trihydroxybenzene; pyrogallic acid; 1,2,3-benzenetriol; Fouramine Brown AP; fourrine PG; fourrine 85; Pyro; C.I. Oxidation Base 32; Piral; fouramine base ap; C.I. 76515; Benzenetriol; 1,2,3-Trihydroxybenzen; Benzene, 1,2,3-trihydroxy-; CI Oxidation Base 32; NSC 5035; UNII-01Y4A2QXY0; HSDB 794; CCRIS 1940; 2,3-Dihydroxyphenol; 1,2,3-Trihydroxybenzen [Czech]; 1,2,3-TRIHYDROXY-BENZENE; Pyrogallol, ACS reagent; EINECS 201-762-9; BRN 0907431; CI 76515; AI3-00709; CHEMBL307145; 01Y4A2QXY0

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1057
ChEBI ID: CHEBI:16164
CAS Number: CAS 87-66-1
TTD Drug ID: DMG5KDY
INTEDE Drug ID: DR2253

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Glucansucrase (gtf106B)	DEWRN24	Q5SBN3_LACRE	Investigative	[2]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80.
2	Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Lasers Med Sci. 2017 May;32(4):827-832.