Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMG6PZT)

Drug Name

6-Phenylaminomethyl-quinazoline-2,4-diamine Drug Info

Synonyms

CHEMBL80746; 6-(anilinomethyl)quinazoline-2,4-diamine; 27133-39-7; AC1LAG5J; 6-Phenylaminomethyl-quinazoline-2,4-diamine; SCHEMBL4788363; CTK0I5781; DTXSID30333156; ZINC3814839; BDBM50101637; [(2,4-Diaminoquinazolin-6-yl)methyl]phenylamine; 2,4-Quinazolinediamine, 6-[(phenylamino)methyl]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 487412
CAS Number: CAS 27133-39-7
TTD Drug ID: DMG6PZT

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polypeptide deformylase (PDF)	TT9SL3Q	DEFM_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Polypeptide deformylase (PDF)	DTT	PDF	8.87E-16	-0.54	-0.86

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model. J Med Chem. 2003 Jul 31;46(16):3455-62.