General Information of Drug (ID: DMG9KMN)

Drug Name
(S)-2-amino-2-o-tolylacetic acid Drug Info
Synonyms
(S)-Amino-o-tolyl-acetic acid; 339274-33-8; CHEMBL204179; (S)-2-AMINO-2-(O-TOLYL)ACETIC ACID; (2S)-2-amino-2-(2-methylphenyl)acetic acid; (S)-2-amino-2-o-tolylacetic acid; 2-Methyl-L-phenylglycine; AC1LT3T3; SCHEMBL3611200; FLYIRERUSAMCDQ-QMMMGPOBSA-N; ZINC4202377; BDBM50179691; AKOS006284304; AB30505; SC-21704; AJ-48395; AB1006782
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1501939
TTD Drug ID
DMG9KMN

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 5.083 4.833 5.343 2.536
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 9.36E-01 -0.03 -0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 2.81E-05 -0.15 -0.68
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.