Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGCTX5)

Drug Name
Combined PR1/WT1 vaccine Drug Info
Synonyms Combined PR1/WT1 vaccine (leukemia); Combined PR1/WT1 vaccine (leukemia), NIH; Proteinase 1/Wilms tumor 1 vaccine (leukemia), NIH
Indication
Disease Entry ICD 11 Status REF
Myeloid leukaemia 2B33.1 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMGCTX5

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leukocyte proteinase-3 (PRTN3) TT5MLC4 PRTN3_HUMAN Not Available [2]
Wilms tumor protein (WT1) TTZ8UT4 WT1_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Wilms tumor protein (WT1) DTT WT1 3.256 2.655 5.113 2.963
Leukocyte proteinase-3 (PRTN3) DTT PRTN3 5.558 2.828 4.138 5.236
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Myeloid leukaemia
ICD Disease Classification 2B33.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Wilms tumor protein (WT1) DTT WT1 5.12E-79 1.54 7.84
Leukocyte proteinase-3 (PRTN3) DTT PRTN3 1.98E-40 -2.04 -1.63
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Review of the Results of WT1 Peptide Vaccination Strategies for Myelodysplastic Syndromes and Acute Myeloid Leukemia from Nine Different Studies. Front Immunol. 2015 Feb 4;6:36.
2 Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008 Jan 1;111(1):236-42.