Details of the Drug

General Information of Drug (ID: DMGCTX5)

Drug Name
Combined PR1/WT1 vaccine
Synonyms Combined PR1/WT1 vaccine (leukemia); Combined PR1/WT1 vaccine (leukemia), NIH; Proteinase 1/Wilms tumor 1 vaccine (leukemia), NIH
Indication
Disease Entry ICD 11 Status REF
Myeloid leukaemia 2B33.1 Phase 2 [1]
Drug Type
Vaccine
Cross-matching ID
TTD ID
D0O8AY

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leukocyte proteinase-3 (PRTN3) TT5MLC4 PRTN3_HUMAN Not Available [2]
Wilms tumor protein (WT1) TTZ8UT4 WT1_HUMAN Not Available [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Myeloid leukaemia
ICD Disease Classification 2B33.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Wilms tumor protein (WT1) DTT WT1 5.12E-79 1.54 7.84
Leukocyte proteinase-3 (PRTN3) DTT PRTN3 1.98E-40 -2.04 -1.63
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Review of the Results of WT1 Peptide Vaccination Strategies for Myelodysplastic Syndromes and Acute Myeloid Leukemia from Nine Different Studies. Front Immunol. 2015 Feb 4;6:36.
2 Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008 Jan 1;111(1):236-42.