Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGFAVQ)

Drug Name

RG7304 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
A-Raf messenger RNA (ARAF mRNA)	TT5TURO	ARAF_HUMAN	Inhibitor	[2]
B-Raf messenger RNA (BRAF mRNA)	TT0EOB8	BRAF_HUMAN	Inhibitor	[2]
ERK activator kinase (MEK)	TTZCRP3	NOUNIPROTAC	Modulator	[2]
MAPK/ERK kinase kinase (MAP3K)	TTROQ37	NOUNIPROTAC	Inhibitor	[2]
Microtubule-associated protein (MAP)	TT1EDJZ	MAP1A_HUMAN; MAP1B_HUMAN	Modulator	[2]
Raf messenger RNA (Raf mRNA)	TTAN5W2	RAF1_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
B-Raf messenger RNA (BRAF mRNA)	DTT	BRAF	6.409	7.097	6.062	6.049

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Solid tumour/cancer

ICD Disease Classification

2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Raf messenger RNA (Raf mRNA)	DTT	RAF1	2.12E-04	0.49	2.78
B-Raf messenger RNA (BRAF mRNA)	DTT	BRAF	1.56E-01	-0.23	-0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029782)
2	Clinical pipeline report, company report or official report of Roche.