Details of the Drug

General Information of Drug (ID: DMGFAVQ)

• Drug Name: RG7304

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 228.25
  Logarithm of the Partition Coefficient (xlogp); 1.3
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 4
• Chemical Identifiers:
  Formula: C12H12N4O
  IUPAC Name: 4-[[(Z)-benzylideneamino]-methylamino]-1H-pyridazin-6-one
  Canonical SMILES: CN(C1=CC(=O)NN=C1)/N=C\\C2=CC=CC=C2
  InChI: InChI=1S/C12H12N4O/c1-16(11-7-12(17)15-13-9-11)14-8-10-5-3-2-4-6-10/h2-9H,1H3,(H,15,17)/b14-8-
  InChIKey: CTGDOGPKSFBVDA-ZSOIEALJSA-N
• Cross-matching ID:
  PubChem CID: 74890577
  TTD ID: D06EFW

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
A-Raf messenger RNA (ARAF mRNA)	TT5TURO	ARAF_HUMAN	Inhibitor	[2]
B-Raf messenger RNA (BRAF mRNA)	TT0EOB8	BRAF_HUMAN	Inhibitor	[2]
ERK activator kinase (MEK)	TTZCRP3	NOUNIPROTAC	Modulator	[2]
MAPK/ERK kinase kinase (MAP3K)	TTROQ37	NOUNIPROTAC	Inhibitor	[2]
Microtubule-associated protein (MAP)	TT1EDJZ	MAP1A_HUMAN ; MAP1B_HUMAN	Modulator	[2]
Raf messenger RNA (Raf mRNA)	TTAN5W2	RAF1_HUMAN	Modulator	[2]

Molecular Expression Atlas of This Drug

• The Studied Disease: Solid tumour/cancer
• ICD Disease Classification: 2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Raf messenger RNA (Raf mRNA)	DTT	RAF1	2.12E-04	0.49	2.78
B-Raf messenger RNA (BRAF mRNA)	DTT	BRAF	1.56E-01	-0.23	-0.43

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029782)
• [2] Clinical pipeline report, company report or official report of Roche.