Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGLUQS)

Drug Name
Rilonacept Drug Info
Synonyms Rilonacept (USAN/INN)
Indication
Disease Entry ICD 11 Status REF
Arthritis FA20 Approved [1]
Acute gout flare FA25.0 Phase 3 [1]
Cross-matching ID
TTD Drug ID
DMGLUQS

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin-1 beta (IL1B) TTRYK0X IL1B_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Interleukin-1 beta (IL1B) DTT IL1B 6.757 6.019 6.475 7.026
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Arthritis
ICD Disease Classification FA20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interleukin-1 beta (IL1B) DTT IL1B 4.74E-01 8.78E-03 0.02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6790).
2 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.