Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGN5QD)

Drug Name
protirelin Drug Info
Synonyms 24305-27-9; Hirtonin; TRH-SR, Takeda; protirelin
Indication
Disease Entry ICD 11 Status REF
Central nervous system disease 8A04-8D87 Approved [1]
Therapeutic Class
Neurology Agents
Cross-matching ID
PubChem CID
638678
ChEBI ID
CHEBI:35940
CAS Number
CAS 24305-27-9
TTD Drug ID
DMGN5QD
INTEDE Drug ID
DR2128

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thyrotropin-releasing hormone receptor (TRHR) TT4J8MF TRFR_HUMAN Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Pyrrolidone-carboxylate peptidase (PGPI) DEVDR46 PGPI_HUMAN Phase 2 [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Thyrotropin-releasing hormone receptor (TRHR) DTT TRHR 3.406 1.632 1.678 1.485
Pyrrolidone-carboxylate peptidase (PGPI) DME PGPEP1 6.453 6.959 7.015 7.086
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Central nervous system disease
ICD Disease Classification 8A04-8D87
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Thyrotropin-releasing hormone receptor (TRHR) DTT TRHR 2.98E-01 0.11 0.61
Pyrrolidone-carboxylate peptidase (PGPI) DME PGPEP1 4.37E-02 1.66E-01 8.17E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Company report (takeda)
3 Marginal involvement of pyroglutamyl aminopeptidase I in metabolism of thyrotropin-releasing hormone in rat brain. Biol Pharm Bull. 2004 Aug;27(8):1197-201.