Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH0G8W)

Drug Name
KURARINONE Drug Info
Synonyms (-)-kurarinone; Kurarinone; CHEMBL243796; SCHEMBL10307523; BDBM50208612
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11982640
ChEBI ID
CHEBI:66150
CAS Number
CAS 34981-26-5
TTD Drug ID
DMH0G8W
VARIDT Drug ID
DR00951

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Beta-secretase (BACE) TT8JRS7 NOUNIPROTAC Inhibitor [2]
SLC5A2 messenger RNA (SLC5A2 mRNA) TTF8JAT SC5A2_HUMAN Inhibitor [1]
Sodium/glucose cotransporter 1 (SGLT1) TT2UE56 SC5A1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
SLC5A2 messenger RNA (SLC5A2 mRNA) DTT SLC5A2 5.466 5.271 7.359 3.573
Beta-secretase (BACE) DTT BACE 5.928 4.638 6.443 5.3
Sodium/glucose cotransporter 1 (SGLT1) DTT SLC5A1 6.42 6.477 5.85 10.555
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
SLC5A2 messenger RNA (SLC5A2 mRNA) DTT SLC5A2 3.26E-01 -0.09 -0.37
Sodium/glucose cotransporter 1 (SGLT1) DTT SLC5A1 9.67E-01 0.08 0.42
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.
2 BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens. Bioorg Med Chem. 2008 Jul 15;16(14):6669-74.