General Information of Drug Therapeutic Target (DTT) (ID: TTF8JAT)

DTT Name SLC5A2 messenger RNA (SLC5A2 mRNA)
Synonyms Solute carrier family 5 member 2 (mRNA); Na(+)/glucose cotransporter 2 (mRNA); Low affinity sodium-glucose cotransporter (mRNA)
Gene Name SLC5A2
DTT Type
Clinical trial target
[1]
BioChemical Class
mRNA target
UniProt ID
SC5A2_HUMAN
TTD ID
T81100
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
Function Has a Na(+) to glucose coupling ratio of 1:1. Sodium-dependent glucose transporter.
Reactome Pathway
Na+-dependent glucose transporters (R-HSA-428808 )
Inositol transporters (R-HSA-429593 )
Hexose transport (R-HSA-189200 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bexagliflozin DMK56G0 Type 2 diabetes 5A11 Approved [1]
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1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS-SGLT2 DMDKAIC Type-2 diabetes 5A11 Phase 1 [2]
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15 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
10-methoxy-N(1)-methylburnamine-17-O-veratrate DMJW25X Discovery agent N.A. Investigative [3]
ACEROGENIN B DMVQ30P Discovery agent N.A. Investigative [4]
Acerogenin C DMNETSX Discovery agent N.A. Investigative [4]
Alstiphyllanine D DM2FLDJ Discovery agent N.A. Investigative [3]
Alstiphyllanine E DMTNQ5E Discovery agent N.A. Investigative [3]
Alstiphyllanine F DMKRAEW Discovery agent N.A. Investigative [3]
Burnamine-17-O-3',4',5'-trimethoxybenzoate DMBO0WI Discovery agent N.A. Investigative [3]
FORMONONETIN DM7WFZ8 Discovery agent N.A. Investigative [5]
KURAIDIN DMLDUJ1 Discovery agent N.A. Investigative [5]
KURARINONE DMH0G8W Discovery agent N.A. Investigative [5]
Kushenol N DMY13UR Discovery agent N.A. Investigative [5]
MAACKIAIN DMDHGM2 Discovery agent N.A. Investigative [5]
O-spiroketal glucoside DM3FS62 Discovery agent N.A. Investigative [6]
SERGLIFLOZIN A DM6FVCE Discovery agent N.A. Investigative [7]
Sophoraflavanone G DMBTMN5 Discovery agent N.A. Investigative [5]
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⏷ Show the Full List of 15 Investigative Drug(s)

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Type 2 diabetes 5A11 Liver tissue 3.26E-01 -0.09 -0.37
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
3 Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158.
4 Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1070-4.
5 Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.
6 ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Bioorg Med Chem. 2010 Jun 15;18(12):4422-32.
7 Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: 1,3,4-Thiadiazolylmethylphenyl glucoside congeners. Bioorg Med Chem. 2010 Mar 15;18(6):2178-2194.