Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH40I3)

Drug Name

CM-GLP-1 Drug Info

Synonyms

CellBead Neuro; GLP-1-expressing stem cell therapy (drug eluting bead, neurological trauma/neurodegeneration); CM-1-expressing stem cell therapy (drug eluting bead, neurological trauma/neurodegeneration), CellMed; GLP-1-expressing stem cell therapy (drug eluting bead, neurological trauma/neurodegeneration), CellMed

Indication

Disease Entry	ICD 11	Status	REF
Brain injury	NA07.Z	Discontinued in Phase 1/2	[1]

Cross-matching ID

TTD Drug ID: DMH40I3

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon-like peptide 1 receptor (GLP1R)	TTVIMDE	GLP1R_HUMAN	Modulator	[2]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glucagon-like peptide 1 receptor (GLP1R)	DTT	GLP1R	2	2.848	3.472	2.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Brain injury

ICD Disease Classification

NA07.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glucagon-like peptide 1 receptor (GLP1R)	DTT	GLP1R	1.25E-01	0.17	1.26

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023519)
2	Reversal of diabetes in rats using GLP-1-expressing adult pancreatic duct-like precursor cells transformed from acinar to ductal cells. Stem Cells Dev. 2009 Sep;18(7):991-1002.