Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH7OIA)

Drug Name
Infliximab Drug Info
Synonyms Remicade (TN)
Indication
Disease Entry ICD 11 Status REF
Crohn disease DD70 Approved [1]
Lupus nephritis 4A40.0Y Approved [2]
Plaque psoriasis EA90.0 Approved [3]
Psoriatic arthritis FA21 Approved [4]
Toxic epidermal necrolysis Approved [5]
Ulcerative colitis DD71 Approved [6]
Asthma CA23 Phase 3 [3]
Rheumatoid arthritis FA20 Phase 2 [7]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [8]
Therapeutic Class
Immunosuppressive Agents
Cross-matching ID
TTD Drug ID
DMH7OIA
VARIDT Drug ID
DR00451

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor necrosis factor (TNF) TTF8CQI TNFA_HUMAN Not Available [9]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tumor necrosis factor (TNF) DTT TNF 5.692 3.07 4.413 1.202
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Crohn disease
ICD Disease Classification DD70
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tumor necrosis factor (TNF) DTT TNF 1.24E-17 0.42 1.18
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Management of inflammatory bowel disease. Med J Aust. 2018 Sep 1;209(7):318-323.
2 Infliximab biosimilar-induced lupus nephritis: A case report. Mod Rheumatol Case Rep. 2023 Dec 29;8(1):74-76.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5004).
4 Efficacy and safety of biologics in psoriatic arthritis: a systematic literature review and network meta-analysis. RMD Open. 2020 Feb;6(1):e001117.
5 Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome. Cochrane Database Syst Rev. 2022 Mar 11;3(3):CD013130.
6 Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005 Dec 8;353(23):2462-76.
7 ClinicalTrials.gov (NCT00029042) Infliximab to Treat Children With Juvenile Rheumatoid Arthritis
8 Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed. Lancet. 2020 May 2;395(10234):1407-1409.
9 Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nat Clin Pract Rheumatol. 2008 Jun;4(6):300-9.