Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH8IT5)

Drug Name

Donaperminogene seltoplasmid Drug Info

Synonyms

VM202

Indication

Disease Entry	ICD 11	Status	REF
Diabetic foot ulcer	BD54	Phase 3	[1]
Diabetic neuropathy	8C0Z	Phase 3	[2]
Amyotrophic lateral sclerosis	8B60.0	Phase 1/2	[3]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatocyte growth factor (HGF)	TT4V2JM	HGF_HUMAN	Replacement	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Hepatocyte growth factor (HGF)	DTT	HGF	5.784	3.307	4.868	1.926

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Diabetic foot ulcer

ICD Disease Classification

BD54

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Hepatocyte growth factor (HGF)	DTT	HGF	4.90E-01	0.13	2.73
Hepatocyte growth factor (HGF)	DTT	HGF	1.98E-07	1.58	2.92

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT02563522) Safety and Efficacy Study of VM202 in the Treatment of Chronic Non-Healing Foot Ulcers. U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT02427464) Phase 3 Gene Therapy for Painful Diabetic Neuropathy. U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT02039401) Safety Study of VM202 to Treat Amyotrophic Lateral Sclerosis. U.S. National Institutes of Health.
4	Clinical pipeline report, company report or official report of ViroMed.