Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHBK6L)

Drug Name
CTAP-201 Drug Info
Synonyms Vitamin D analogs, Cytochroma; Vitamin D analogs (iv, hyperparathyroidism), Cytochroma
Indication
Disease Entry ICD 11 Status REF
Hyperparathyroidism 5A51 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMHBK6L

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vitamin D3 receptor (VDR) TTK59TV VDR_HUMAN Agonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Vitamin D3 receptor (VDR) DTT VDR 4.536 6.7 5.109 7.303
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Hyperparathyroidism
ICD Disease Classification 5A51
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vitamin D3 receptor (VDR) DTT VDR 1.69E-02 -0.23 -0.66
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00792857) Comparison of I.V. CTAP201 and Doxercalciferol (Hectorol) in Subjects With Chronic Kidney Disease (CKD) and Secondary Hyperparathyroidism (SHPT). U.S. National Institutes of Health.
2 Vascular calcification and secondary hyperparathyroidism of severe chronic kidney disease and its relation to serum phosphate and calcium levels. Br J Pharmacol. 2009 April; 156(8): 1267-1278.