Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHRYX6)

• Drug Name: SLV-323 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Chemotherapy-induced nausea	MD90	Discontinued in Phase 1	[1]
Gastric motility disorder	DA21	Discontinued in Phase 1	[1]
Irritable bowel syndrome	DD91.0	Discontinued in Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMHRYX6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Substance-P receptor (TACR1)	TTZPO1L	NK1R_HUMAN	Modulator	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Substance-P receptor (TACR1)	DTT	TACR1	3.597	4.186	4.271	5.113

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Chemotherapy-induced nausea
• ICD Disease Classification: MD90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Substance-P receptor (TACR1)	DTT	TACR1	7.24E-01	0.02	0.11

References

• [1] Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51.