Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHVNQM)

Drug Name

3-methyl-2(1H)-thioxo-4(3H)-quinazolinone Drug Info

Synonyms

1705-09-5; 2-mercapto-3-methylquinazolin-4(3H)-one; 2-Mercapto-3-methyl-3H-quinazolin-4-one; CHEMBL460734; 3-methyl-2-sulfanylidene-1H-quinazolin-4-one; 2-mercapto-3-methyl-3,4-dihydroquinazolin-4-one; 3-methyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one; 3-Methyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one; 4(1H)-Quinazolinone, 2,3-dihydro-3-methyl-2-thioxo-; 3-methyl-2-thioxo-1H-quinazolin-4-one; 3-methyl-2-thioxo-2,3-dihydro-4(1H)-quinazolinone; 3-methyl-2-sulfanylquinazolin-4(3H)-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 747056
CAS Number: CAS 1705-09-5
TTD Drug ID: DMHVNQM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A ... Bioorg Med Chem. 2009 Jan 15;17(2):675-89.