Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMI4E9K)

Drug Name
MLN0264 Drug Info
Indication
Disease Entry ICD 11 Status REF
Gastrointestinal cancer 2C11 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMI4E9K

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Guanylyl cyclase C (GUCY2C) TTLDPRG GUC2C_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Guanylyl cyclase C (GUCY2C) DTT GUCY2C 4.542 7.698 3.797 7.565
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Gastrointestinal cancer
ICD Disease Classification 2C11
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Guanylyl cyclase C (GUCY2C) DTT GUCY2C 9.52E-03 2.35 5.13
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT02202759) A Study of MLN0264 in Patients With Cancer of the Stomach or Gastroesophageal Junction. U.S. National Institutes of Health.
2 J Clin Oncol 31, 2013 (suppl; abstr TPS3646).