Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMI9PRJ)

• Drug Name: Diflorasone Drug Info
• Synonyms: Diflorasona; Diflorasonum; Maxiflor; Murode; U 34865; Diflorasona [INN-Spanish]; Diflorasone (INN); Diflorasone [INN:BAN]; Diflorasonum [INN-Latin]; Murode (TN); (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; (6alpha,11beta,16beta)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 6a,9a-difluoro-16b-methylprednisolone; 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione

Indication

Disease Entry	ICD 11	Status	REF
Exanthem		Approved	[1]
Granuloma annulare		Approved	[1]
Primary cutaneous T-cell lymphoma		Approved	[1]
Rosacea	ED90.0	Approved	[2]

• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 71415
  ChEBI ID: CHEBI:59750
  CAS Number: CAS 2557-49-5
  TTD Drug ID: DMI9PRJ
  INTEDE Drug ID: DR2429

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phospholipase A2 (PLA2G1B)	TT9V5JH	PA21B_HUMAN	Inhibitor	[3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phospholipase A2 (PLA2G1B)	DTT	PLA2G1B	5.385	3.733	4.178	5.278

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Exanthem

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phospholipase A2 (PLA2G1B)	DTT	PLA2G1B	2.65E-01	-0.08	-0.21

References

• [1] Diflorasone FDA Label
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] Structures from powders: diflorasone diacetate. Steroids. 2009 Jan;74(1):102-11.