General Information of Drug Therapeutic Target (DTT) (ID: TT9V5JH)

DTT Name Phospholipase A2 (PLA2G1B)
Synonyms Secreted phospholipase A(2); Phosphatidylcholine 2-acylhydrolase 1B; PLA2G1B; Group IB phospholipase A2
Gene Name PLA2G1B
DTT Type
Successful target
[1]
BioChemical Class
Carboxylic ester hydrolase
UniProt ID
PA21B_HUMAN
TTD ID
T31479
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 3.1.1.4
Sequence
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPV
DELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNC
DRNAAICFSKAPYNKAHKNLDTKKYCQS
Function
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
KEGG Pathway
Glycerophospholipid metabolism (hsa00564 )
Ether lipid metabolism (hsa00565 )
Arachidonic acid metabolism (hsa00590 )
Linoleic acid metabolism (hsa00591 )
alpha-Linolenic acid metabolism (hsa00592 )
Metabolic pathways (hsa01100 )
Ras signaling pathway (hsa04014 )
Vascular smooth muscle contraction (hsa04270 )
Pancreatic secretion (hsa04972 )
Fat digestion and absorption (hsa04975 )
Reactome Pathway
Acyl chain remodelling of PE (R-HSA-1482839 )
Acyl chain remodelling of PI (R-HSA-1482922 )
Acyl chain remodelling of PC (R-HSA-1482788 )
BioCyc Pathway
MetaCyc:HS10199-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
5 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [2]
Clobetasol DMUXP52 Rosacea ED90.0 Approved [1]
Clocortolone DM9ZMQH Exanthem Approved [3]
Diflorasone DMI9PRJ Exanthem Approved [4]
Miltefosine DMND304 Chronic urticaria Approved [5]
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7 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
AllerB DM78DOT Allergy 4A80-4A85 Phase 2b [6]
MANOALIDE DMB4A8I Arthritis FA20 Phase 2 [7]
MRX-4 DMQZWYE Allergic rhinitis CA08.0 Phase 2 [8]
MRX-6 DMLVQKF Contact dermatitis EK0Z Phase 2 [9]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [10]
Varespladib DM5JJ83 Snakebite N.A. Phase 2 [11]
Rilapladib DMB9861 Arteriosclerosis BD40 Phase 1 [12]
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⏷ Show the Full List of 7 Clinical Trial Drug(s)
8 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Darapladib DMSWLA3 Arteriosclerosis BD40 Discontinued in Phase 3 [13]
BMY-30129 DMA4UCP Pruritus EC90 Discontinued in Phase 2 [14]
EPC-K1 DMZKBU9 Nerve injury ND56.4 Discontinued in Phase 2 [15]
SC-106 DMTZ7E4 Rheumatoid arthritis FA20 Discontinued in Phase 2 [16]
WAY-123641 DMPE5XM Asthma CA23 Discontinued in Phase 2 [17]
PF-05212372 DMD83VY Asthma CA23 Discontinued in Phase 1 [18]
SB-435495 DM92BXN Arteriosclerosis BD40 Discontinued in Phase 1 [19]
YM-26734 DMEHAI2 Rheumatoid arthritis FA20 Terminated [20]
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⏷ Show the Full List of 8 Discontinued Drug(s)
28 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [2]
3,9-dihydroxy-2,10-diprenylpterocap-6a-ene DMXZ8RJ Discovery agent N.A. Investigative [21]
4'-hydroxy-6,3',5'-triprenylisoflavonone DM7PWOL Discovery agent N.A. Investigative [21]
ABYSSINONE V DMH3CK2 Discovery agent N.A. Investigative [21]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [2]
AGN-190383 DM53R94 Discovery agent N.A. Investigative [22]
Alpha-D-Mannose DMF5DLW Discovery agent N.A. Investigative [2]
BM-162115 DMDNPML Inflammation 1A00-CA43.1 Investigative [23]
BOLINAQUINONE DMVB6UG Discovery agent N.A. Investigative [24]
CACOSPONGIONOLIDE DMIPJUS Discovery agent N.A. Investigative [25]
CACOSPONGIONOLIDE B DMCSXNW Discovery agent N.A. Investigative [25]
Cacospongionolide E DM2DYAV Discovery agent N.A. Investigative [25]
folipastatin DMEPZ2I Discovery agent N.A. Investigative [26]
HELENAQUINONE DM5MOLY Discovery agent N.A. Investigative [27]
Heptanoic Acid DM4NY9H Discovery agent N.A. Investigative [28]
Hexane-1,6-Diol DMWAPGI Discovery agent N.A. Investigative [2]
Hyrtiosulawesine DMWLJ5S Discovery agent N.A. Investigative [29]
Lpc-Ether DM1JGDM Discovery agent N.A. Investigative [2]
LY178002 DMI01YM Discovery agent N.A. Investigative [30]
LY256548 DM1KCHN Discovery agent N.A. Investigative [30]
Mepacrine DMU8L7C Discovery agent N.A. Investigative [31]
methylglyoxal DMRC3OZ Discovery agent N.A. Investigative [2]
N-Tridecanoic Acid DMNZ37C Discovery agent N.A. Investigative [28]
P-Anisic Acid DM8HWS9 Discovery agent N.A. Investigative [2]
Petrosaspongiolide M DMR8ZBT Discovery agent N.A. Investigative [32]
Petrosaspongiolide P DMMVZFN Discovery agent N.A. Investigative [33]
SB-203347 DM3AWMF Discovery agent N.A. Investigative [34]
WA-8242-A1 DMNRBDP Discovery agent N.A. Investigative [35]
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⏷ Show the Full List of 28 Investigative Drug(s)

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Coronary artery disease BA80-BA8Z Peripheral blood 2.72E-01 -0.04 -0.17
Asthma CA23 Nasal and bronchial airway 5.61E-01 1.50E-02 0.03
Rheumatoid arthritis FA20 Synovial tissue 2.65E-01 -0.08 -0.21
Atopic dermatitis EA90 Skin 1.05E-05 -0.11 -0.87
Sensitive skin EA90 Skin 2.98E-01 0.07 0.52
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References

1 Utilization of epidermal phospholipase A2 inhibition to monitor topical steroid action. Br J Dermatol. 1984 Jul;111 Suppl 27:195-203.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Clocortolone pivalate: a paired comparison clinical trial of a new topical steroid in eczema/atopic dermatitis. Cutis. 1980 Jan;25(1):96-8.
4 Structures from powders: diflorasone diacetate. Steroids. 2009 Jan;74(1):102-11.
5 Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22.
6 Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):747-54.
7 Manoalide, a phospholipase A2 inhibitor, inhibits arachidonate incorporation and turnover in brain phospholipids of the awake rat. Neurochem Res. 1998 Oct;23(10):1251-7.
8 Phospholipase A2, group IVA (cytosolic, calcium-dependent) (PLA2G4A). SciBX 1(41); doi:10.1038/scibx.2008.999. Nov. 13 2008
9 A novel treatment of contact dermatitis by topical application of phospholipase A2 inhibitor: a double-blind placebo-controlled pilot study. Int J Immunopathol Pharmacol. 2007 Jan-Mar;20(1):191-5.
10 Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4.
11 Varespladib in the Treatment of Snakebite Envenoming: Development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes. Toxins (Basel). 2022 Nov 11;14(11):783.
12 Effect of treatment for 12 weeks with rilapladib, a lipoprotein-associated phospholipase A2 inhibitor, on arterial inflammation as assessed with 18F-fluorodeoxyglucose-positron emission tomography imaging.J Am Coll Cardiol.2014 Jan 7-14;63(1):86-8.
13 Darapladib, a reversible lipoprotein-associated phospholipase A2 inhibitor, for the oral treatment of atherosclerosis and coronary artery disease. IDrugs. 2009 Oct;12(10):648-55.
14 Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity. J Pharmacol Exp Ther. 1994 Nov;271(2):852-9.
15 Posttreatment with EPC-K1, an inhibitor of lipid peroxidation and of phospholipase A2 activity, reduces functional deficits after global ischemia in rats. Brain Res Bull. 1995;36(3):257-60.
16 US patent application no. 6,673,908, Tumor necrosis factor receptor 2.
17 Phosphodiesterase-IV inhibition, respiratory muscle relaxation and bronchodilation by WAY-PDA-641. J Pharmacol Exp Ther. 1994 Feb;268(2):888-96.
18 Phagedena due to leishmaniasis. Immunologic and experimental studies. Ann Dermatol Syphiligr (Paris). 1976;103(1):23-30.
19 The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. Respir Res. 2012 Nov 12;13:100.
20 Simplified YM-26734 Inhibitors of Secreted Phospholipase A2 Group IIA
21 Phospholipase A2 Inhibitors from an Erythrina Species from Samoa J. Nat. Prod. 60(6):537-539 (1997).
22 AGN 190383, a novel phospholipase inhibitor with topical anti-inflammatory activity. Agents Actions. 1991 Sep;34(1-2):70-2.
23 Investigation on the effect of experimental phospholipase A2 inhibitors on the formyl-methionyl-leucyl-phenylalanine-stimulated chemotaxis of human leukocytes in vitro. Arzneimittelforschung. 1998 Jan;48(1):77-81.
24 New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte... J Nat Prod. 2001 May;64(5):612-5.
25 A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5.
26 Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2.Taxonomy, fermentation, isolation, structure determination and biological properties.J Antibiot (Tokyo).1992 Aug;45(8):1195-201.
27 New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. Bioorg Med Chem. 2010 Aug 15;18(16):6006-11.
28 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
29 Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus. J Nat Prod. 2006 Dec;69(12):1676-9.
30 The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2.
31 Involvement of protein kinase C activation in L-leucine-induced stimulation of protein synthesis in l6 myotubes. Cytotechnology. 2003 Nov;43(1-3):97-103.
32 Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffo... J Med Chem. 2007 May 3;50(9):2176-84.
33 Petrosaspongiolides M-R: new potent and selective phospholipase A2 inhibitors from the New Caledonian marine sponge Petrosaspongia nigra. J Nat Prod. 1998 May;61(5):571-5.
34 SB 203347, an inhibitor of 14 kDa phospholipase A2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine... J Pharmacol Exp Ther. 1995 Sep;274(3):1254-62.
35 WA8242A1, A2 and B, novel secretary phospholipase A2 inhibitors produced by Streptomyces violaceusniger. III. Structure elucidation and total synth... J Antibiot (Tokyo). 1998 Jul;51(7):655-64.