Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIB6JL)

Drug Name
ISIS 100742 Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DMIB6JL

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ADAM10 messenger RNA (ADAM10 mRNA) TTVXEGU ADA10_HUMAN Not Available [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
ADAM10 messenger RNA (ADAM10 mRNA) DTT ADAM10 5.86 6.053 6.109 5.874
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
ADAM10 messenger RNA (ADAM10 mRNA) DTT ADAM10 9.12E-20 0.59 0.82
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 US patent application no. 6,228,648, Antisense modulation of ADAM10 expression.