Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTVXEGU)

DTT Name ADAM10 messenger RNA (ADAM10 mRNA)
Synonyms
Mammalian disintegrinmetalloprotease (mRNA); MADM (mRNA); Kuzbanian protein homolog (mRNA); KUZ (mRNA); Disintegrin and metalloproteinase domaincontaining protein 10 (mRNA); Disintegrin and metalloproteinase domain-containing protein 10 (mRNA); CDw156 (mRNA); CD156c (mRNA); ADAM 10 (mRNA)
Gene Name ADAM10
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
ADA10_HUMAN
TTD ID
T77997
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 3.4.24.81
Sequence
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
Function
Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. May regulate the EFNA5-EPHA3 signaling. Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form.
KEGG Pathway
Alzheimer's disease (hsa05010 )
Epithelial cell signaling in Helicobacter pylori infection (hsa05120 )
Reactome Pathway
Degradation of the extracellular matrix (R-HSA-1474228 )
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948 )
Constitutive Signaling by NOTCH1 PEST Domain Mutants (R-HSA-2644606 )
Constitutive Signaling by NOTCH1 t(7 (R-HSA-2660826 )
Constitutive Signaling by NOTCH1 HD Domain Mutants (R-HSA-2691232 )
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862 )
NOTCH2 Activation and Transmission of Signal to the Nucleus (R-HSA-2979096 )
EPH-ephrin mediated repulsion of cells (R-HSA-3928665 )
M1580_K2555) Translocation Mutant (9)(NOTCH1 )
Collagen degradation (R-HSA-1442490 )
BioCyc Pathway
MetaCyc:ENSG00000137845-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
6 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 100742 DMIB6JL Discovery agent N.A. Investigative [2]
ISIS 100743 DMI7PGZ Discovery agent N.A. Investigative [2]
ISIS 100748 DMFW5VK Discovery agent N.A. Investigative [2]
ISIS 100749 DMSMJ37 Discovery agent N.A. Investigative [2]
ISIS 100750 DMFJES5 Discovery agent N.A. Investigative [2]
PMID18068976C25 DMTZQUJ Discovery agent N.A. Investigative [1]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Breast cancer 2C82 Breast tissue 9.12E-20 0.59 0.82
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References

1 Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations. Bioorg Med Chem Lett. 2008 Jan 15;18(2):560-4.
2 US patent application no. 6,228,648, Antisense modulation of ADAM10 expression.