Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIHO0P)

Drug Name

PIPEROXAN Drug Info

Synonyms

Piperoxan; Benodaine; Piperoxane; 59-39-2; Fourneau 933; Piperoxan [INN:BAN]; Piperoxanum [INN-Latin]; Piperoxane [INN-French]; F933; Piperoxano [INN-Spanish]; 2-Piperidinomethyl-1,4-benzodioxan; 933F; Piperidine, 1-(1,4-benzodioxan-2-ylmethyl)-; BRN 0222516; CHEMBL31836; NCGC00160643-01; Piperidine,1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-; 1,4-Benzodioxane, 2-(piperidinomethyl)-; Piperidine, 1-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)-; 1,4-BENZODIOXAN, 2-(PIPERIDINOMETHYL)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6040
CAS Number: CAS 59-39-2
TTD Drug ID: DMIHO0P

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401.