Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIQ8GL)

Drug Name

MR-22388 Drug Info

Synonyms

MR-22388; CHEMBL287508; 3-(3-hydroxy-4-methoxyphenyl)-8h-thieno[2,3-b]pyrrolizin-8-one; SCHEMBL7001747; Thienopyrrolizine derivative, 4g; IXGRUAKWRHZSAP-UHFFFAOYSA-N; BDBM50103203; 3-(3-Hydroxy-4-methoxy-phenyl)-thieno[2,3-b]pyrrolizin-8-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9904289
TTD Drug ID: DMIQ8GL

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tubulin (TUB)	TTML2WA	NOUNIPROTAC	Inhibitor	[1]
Tubulin beta (TUBB)	TTYFKSZ	NOUNIPROTAC	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tubulin (TUB)	DTT	TUB	7.743	8.411	8.625	8.347

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tubulin (TUB)	DTT	NO-GeName	7.94E-02	0.35	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design, synthesis, and evaluation of novel thienopyrrolizinones as antitubulin agents. J Med Chem. 2004 Mar 11;47(6):1448-64.