Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIUABO)

Drug Name
helodermin Drug Info
Synonyms Exendin 2
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
16132369
CAS Number
CAS 89468-62-2
TTD Drug ID
DMIUABO

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Helodermin-preferring VIP receptor (VIPR2) TT4O5P0 VIPR2_HUMAN Agonist [2]
Vasoactive intestinal polypeptide receptor 1 (VIPR1) TTCL30I VIPR1_HUMAN Agonist [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Vasoactive intestinal polypeptide receptor 1 (VIPR1) DTT VIPR1 6.594 8.553 6.399 8.394
Helodermin-preferring VIP receptor (VIPR2) DTT VIPR2 1.632 3.888 3.293 3.087
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vasoactive intestinal polypeptide receptor 1 (VIPR1) DTT VIPR1 6.47E-01 -0.16 -0.14
Vasoactive intestinal polypeptide receptor 1 (VIPR1) DTT VIPR1 4.24E-01 -0.12 -0.26
Helodermin-preferring VIP receptor (VIPR2) DTT VIPR2 1.54E-01 -0.08 -0.4
Helodermin-preferring VIP receptor (VIPR2) DTT VIPR2 6.31E-01 6.73E-03 0.03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2280).
2 Analogues of VIP, helodermin, and PACAP discriminate between rat and human VIP1 and VIP2 receptors. Ann N Y Acad Sci. 1998 Dec 11;865:247-52.
3 Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties. Eur J Pharmacol. 1996 Apr 29;302(1-3):207-14.