Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIWQ7G)

Drug Name
3-Methyl-1,2,3,4-tetrahydro-isoquinoline Drug Info
Synonyms
3-Methyl-1,2,3,4-tetrahydroisoquinoline; 29726-60-1; 1,2,3,4-Tetrahydro-3-methylisoquinoline; Isoquinoline, 1,2,3,4-tetrahydro-3-methyl-; 3-Methyl-1,2,3,4-tetrahydro-isoquinoline; CHEMBL60434; UEKQPSAKUNXFHL-UHFFFAOYSA-N; BAS 03334621; AC1Q1HKS; AC1LC3M2; SCHEMBL1011182; SCHEMBL15334650; KS-00000JVD; MolPort-001-990-837; HMS1698C16; BDBM50023304; ANW-75096; AKOS016843414; AKOS000650337; AB30586; NE31770; MCULE-3517571472; NCGC00184271-01; DA-07231; KB-70931; BS-13528; TC-163841; ST24042290; FT-0729461; EN300-86328
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
568974
TTD Drug ID
DMIWQ7G

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-2A (ADRA2A) TTWG9A4 ADA2A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2B (ADRA2B) TTWM4TY ADA2B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 5.013 2.379 5.594 2.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46.