Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIY134)

Drug Name

ANA-04 Drug Info

Synonyms

ANA-506; ANA-506); ANB-004; Human monoclonal antibody (inflammatory disease/autoimmune disease), AnaptysBio; Multi-specific antibody (autoimmune disease/inflammatory disease), AnaptysBio/VLST Corp

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMIY134

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 17 receptor (IL17R)	TT69OHW	I17RA_HUMAN; I17RB_HUMAN; I17RC_HUMAN; I17RD_HUMAN; I17RE_HUMAN	Not Available	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Autoimmune diabetes

ICD Disease Classification

5A10

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interleukin 17 receptor (IL17R)	DTT	IL17RA; IL17RB; IL17RC; IL17RD; IL17RE	3.40E-10	-0.23	-0.72

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2294).